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leprae. Anin silicostudy was done to know the molecular interactions among DNA gyrase and WQ compounds. WQ-3334 and WQ-3810 had been shown to obtain larger inhibitory activity againstM. lepraeDNA gyrase than others. Also, Examination employing quinolone-resistantM. lepraeDNA gyrases confirmed that WQ-3334 had bigger inhibitory activity than WQ-3810